黑色素细胞刺激素（melanocyte-stimulating hormones, melanotropins, intermedins，简称 MSH）是一种神经肽，属于肽类激素。具有 α-黑色素细胞刺激素(α-MSH)、 β-黑色素细胞刺激素 (β-MSH) 和 γ-黑色素细胞刺激素 (γ-MSH) 三种，都是由垂体产生的。

当前正在开发和研究合成 α-MSH 的类似物，比如afamelanotide (美拉诺坦 I; Scenesse), 美拉诺坦 II 和 布美诺肽 (PT-141)。

The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the intermediate lobe of the pituitary gland.