大地懒科（学名：Megatheriidae）是一科已灭绝的地懒，在大约23百万年前至11000年前生活，存活了大约22.89百万年。

巨大的大地懒及泛美地懒等是此科物种于约30百万年前的渐新世后期开始才出现在南美洲大陆上，而较早期的此科物种，如较细小的中新地懒（Hapalops）则只有约1.2米高左右。过去曾被认为是此科的懒兽现在则被分到懒兽科（Nothrotheriidae）内。

从这些地懒的骨架结构中可显示出部份物种非常巨型：牠们拥有粗壮的骨骼，更见粗壮的关节部份（特别是后脚）则提供强大的承托力去支撑四肢，加上牠们的体型及巨爪，使牠们足以扺御不同捕猎者的攻击。

Megatheriidae is a family of extinct ground sloths that lived from approximately 23 mya—11,000 years ago, existing for approximately 22.89 million years.

Megatheriids appeared later in the Oligocene, some 30 million years ago, also in South America. The group includes the heavily built Megatherium (given its name 'great beast' by Georges Cuvier) and Eremotherium. An early megatheriid, the more slightly built Hapalops, reached a length of about 1.2 meters. The nothrotheres have recently been placed in their own family, Nothrotheriidae.