Meckel syndrome
![This condition is inherited in an autosomal recessive pattern, meaning two copies of the gene in each cell are altered](/Images/godic/202501/26/Autorecessive.svg5657.png")
Meckel syndrome (also known as Meckel–Gruber Syndrome, Gruber Syndrome, Dysencephalia Splanchnocystica) is a rare, lethal, ciliopathic, genetic disorder, characterized by renal cystic dysplasia, central nervous system malformations (occipital encephalocele), polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia due to oligohydramnios.