姆博穆省 （法文：Prefecture de Mbomou）是中非共和国16省之一，首府班加苏 (法文:Bangassou).

Mbomou can also refer to the Mbomou River.

Mbomou is one of the 14 prefectures of the Central African Republic. It covers an area of 61,150 km² and has a population of 132,740 (2003 census), giving a population density of only 2.2 inhabitants/km². The capital is Bangassou. Nearby are Kembe Falls on the River Kotto. The prefecture is governed by Mr. Remy Sem Ndouto .