Periventricular leukomalacia
（重定向自Leukomalacia）
![Drawing of the lateral and third ventricles of the brain. Periventricular leukomalacia involves death of the white matter surrounding the lateral ventricles in fetuses and infants. (Image from Gray's Anatomy, 1918 edition)](/Images/godic/202501/24/Gray7341104.png")
Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of the disorder. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life.