Hormone replacement therapy (menopause)
![Clot in the greater saphenous vein; oral HRT is associated with increased risk of venous clot due to increased hepatic synthesis of Vitamin K dependent clotting factors.](/Images/godic/202501/22/Great_saphenous_vein_thrombosis_050913120095638.jpg")
![Endometrial tumor on histology. Most commonly, the tumor is in situ with minimal morbidity; patients still have lower all-cause mortality than those not on HRT.](/Images/godic/202501/22/Endometrioid_endometrial_adenocarcinoma_low_mag5638.jpg")
![The WHI found breast cancer increased in post-menopausal women taking combined estrogen-progesterone therapy, but not in post-hysterectomy patients on estrogen therapy alone.](/Images/godic/202501/22/Mammo_breast_cancer5639.jpg")
Hormone replacement therapy (HRT) in menopause is medical treatment in surgically menopausal, perimenopausal and postmenopausal women. Its goal is to mitigate discomfort caused by diminished circulating estrogen and progesterone hormones in menopause. Combination HRT is often recommended as it decreases the amount of endometrial hyperplasia and cancer associated with unopposed estrogen therapy. The main hormones involved are estrogen, progesterone and progestin. Some recent therapies include the use of androgens as well.