Detectives are still waiting for a breakthrough in their investigations.侦探仍在等待调查能有所突破。There's a valuable place for fashion and design that pushes the envelope a bit.在原有尺度上有所突破的时尚和设计受到人们的重视。Scientists at Merck were nearing a breakthrough on a new drug to treat HIV.默克公司的科学家在研制一种对抗艾滋病病毒的新药，即将有所突破。