Some Democrats still have bitter memories of how, against all odds, they came off worst during the inquiry.一些民主党人士至今仍然记得当时困难重重、在调查中惨败的痛苦经历。He took positive steps to educate himself in the jail against all odds.尽管困难重重，他还是积极地在监狱中自学。He was able to do it, against all odds. 尽管极其困难，他还是做到了。