Hepatotoxicity
（重定向自Hepatoxic）
![Drug-induced hepatitis with granulomata. Other causes were excluded with extensive investigations. Liver biopsy. H&E stain.](/Images/godic/202501/17/Drug-induced_hepatitis_low_mag5546.jpg")
![Acetaminophen (3D structure) overdose is the most common cause of drug-induced liver disease](/Images/godic/202501/17/Paracetamol-rod-povray5547.png")
![Ackee fruit](/Images/godic/202501/17/Akee5547.jpg")
![Drug metabolism in liver: transferases are : glutathione, sulfate, acetate, glucoronic acid. P-450 is cytochrome P-450 enzymes. 3 different pathways are depicted for Drugs A, B and C.](/Images/godic/202501/17/Hepatic_drug_metabolism.svg5547.png")
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease.
The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.