Hanksville is a small town in Wayne County, Utah, United States, at the junction of State Routes 24 and 95. The population was 219 at the 2010 census.

The town is just south of the confluence of the Fremont River and Muddy Creek, which together form the Dirty Devil River, which then flows southeast to the Colorado River. Situated in the Colorado Plateau's cold desert ecological region it has, in Köppen climate classification, a temperate arid climate (BWk) with a mean annual temperature of 11.6 °C and an annual mean rainfall of 146.3 mm (years 1961-1990). The Hanksville-Burpee Quarry is located nearby, and the Mars Desert Research Station is 7 miles (11 km) northwest of town. The BLM Henry Mountains field station is located in Hanksville.