Cimabue (Italian: [tʃimaˈbuːe]; c. 1240 – 1302), also known as Cenni di Pepo or Cenni di Pepi, was a Florentine painter and creator of mosaics.

Cimabue is generally regarded as one of the first great Italian painters to break from the Italo-Byzantine style, although he still relied on Byzantine models. The art of this period comprised scenes and forms that appeared relatively flat and highly stylized. Cimabue was a pioneer in the move towards naturalism; his figures were depicted with more lifelike proportions and shading. Even though he was a pioneer in that move, his Maestà paintings evidence Medieval techniques and characteristics. According to Italian painter and historian Giorgio Vasari, Cimabue was the teacher of Giotto, the first great artist of the Italian Proto-Renaissance.