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词汇 Geldanamycin
分类 英语词汇 英语翻译词典
释义

Geldanamycin

英语百科

Geldanamycin

Hsp90-geldanamycin complex. PDB 1yet[2]

Geldanamycin is a 1,4-benzoquinone ansamycin antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

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