Gastric mucosal barrier
![Diagram of alkaline Mucous layer in stomach with mucosal defense mechanisms](/Images/godic/202501/14/Stomach_mucosal_layer_labeled.svg2024.png")
The gastric mucosal barrier is the property of the stomach that allows it to safely contain the gastric acid required for digestion.
If the barrier is broken, as by acetylsalicylic acid (ASA, aspirin) in acid solution, acid diffuses back into the mucosa where it can cause damage to the stomach itself.