The manager replied that he had issued orders exactly on these lines.经理回答说，他已完全按照这些想法发出指示。Wenger stood on the sidelines shouting instructions.温格站在场外大声发出指示。The Department of Defense has issued instructions that no one should enter the area without permission.国防部已经发出指示，未经许可谁也不得进入该地区。