Flesinoxan

Flesinoxan (DU-29,373) is a potent and selective 5-HT_1A receptor partial/near-full agonist of the phenylpiperazine class. Originally developed as a potential antihypertensive drug, flesinoxan was later found to possess antidepressant and anxiolytic effects in animal tests. As a result, it was investigated in several small human pilot studies for the treatment of major depressive disorder, and was found to have robust effectiveness and very good tolerability. Unfortunately however, due to "management decisions", the development of flesinoxan was stopped and it was not pursued any further.