Euphorbia maculata, variously called spotted spurge or prostrate spurge, the latter name not to be confused with Euphorbia prostrata), is an annual plant in the family Euphorbiaceae, native to North America.

It grows in sunny locations and a variety of soils, and functions as a pioneer species in ecological succession. The sap of this plant is a mild skin irritant and can cause a rash in some people. The sap is poisonous and considered carcinogenic.