Keratolytic winter erythema

Keratolytic Winter erythema (KWE), also known as erythrokeratolysis hiemalis, Oudtshoorn disease and Oudtshoorn skin, is a rare autosomal dominant skin disease of unknown etiology which causes erythema (redness) and keratolysis (peeling) of the skin on the palms and soles. Onset, increased prominence and severity usually occurs during winter. It is a type of genodermatosis.