Entacapone and Tolcapone may cause discoloration of urine, sweat or saliva, and diarrhea, which can get severe particularly with the use of Tolcapone.

恩他卡彭和托卡彭可能导致尿液、汗液或唾液变色，以及腹泻尤其是使用托卡彭后会变得更严重。

COMT inhibitors like entacapone and tolcapone are only given with levodopa to prevent the enzyme from breaking it down outside the central nervous system, thus allowing more of it to enter the brain.

COMT抑制剂，例如恩他卡朋和托卡朋与左旋多巴一起用于治疗，只是为了防止左旋多巴在中枢神经系统外被分解，从而使更多左旋多巴进入脑中。

As a side note here, in comparison to Entacapone, Tolcapone can better penetrate the blood–brain barrier, and thus can act both in the central nervous system and in the periphery.

另一方面，与恩他卡彭相比，托卡彭能更好地穿透血液-大脑屏障，因此可以在中枢神经系统和周围发挥作用。

Another agent that is used in combination with Levodopa and Carbidopa is Entacapone, which inhibits peripheral COMT and thus just like Carbidopa, it prolongs the time that Levodopa is available to the brain.

另一种与左旋多巴和卡比多巴联合使用的药剂是恩他卡彭，它能抑制外周血细胞凋亡，因此就像卡比多巴一样，它延长了左旋多巴对大脑有效。