《大美百科全书》（Encyclopedia Americana），美国Scholastic出版的百科全书，是英语世界著名的大型综合性百科全书之一，与《大英百科全书》（Encyclopædia Britannica）、《科里尔百科全书》（Collier's Encyclopedia）合称「ABC百科全书」（the ABCs）。第1版《大美百科全书》于1829年至1833年在美国出版，共13卷，以第7版《布罗克豪斯社交辞典》为本。1846年追加第14卷出版。一个重要的新版本出现在1918至1920年，共30卷，由George Edwin Rines 主编。1991年中文版由光复书局出版。

Encyclopedia Americana is one of the largest general encyclopedias in the English language. Following the acquisition of Grolier in 2000, the encyclopedia has been produced by Scholastic.

The encyclopedia has more than 45,000 articles, most of them more than 500 words and many running to considerable length (the "United States" article is over 300,000 words). The work's coverage of American and Canadian geography and history has been a traditional strength. Written by 6,500 contributors, the Encyclopedia Americana includes over 9,000 bibliographies, 150,000 cross-references, 1,000+ tables, 1,200 maps, and almost 4,500 black-and-white line art and color images. It also has 680 factboxes. Most articles are signed by their contributors.