eIF4G（eukaryotic translation initiation factor 4G，真核起始因子4G）是一种在真核翻译起始进程中发挥重要作用的蛋白质。它主要是在翻译起始早期协同不同起始因子间的作用和增强它们的活性（包括eIF4E的帽结合活性，eIF4A的RNA解旋酶活性，PABP的poly-A结合活性，以及eIF3的mRNA和40S核糖体亚基结合活性）。此外，eIF4G通过一个类RNA识别结构花样（RRM）直接结合或在某些情况下能够特异性结合到mRNA上。

eIF4G在人体中有三个亚型：eIF4G-1、eIF4G-2和eIF4G-3。

Eukaryotic translation initiation factor 4 G (eIF4G) is a protein involved in eukaryotic translation initiation, and is a component of the eIF4F cap binding complex. Orthologs of eIF4G have been studied in multiple species, including humans, yeast, and wheat. However, eIF4G is exclusively found in domain Eukarya, and not in domains Bacteria or Archaea, which do not have capped mRNA. As such, eIF4G structure and function may vary between species, although the human eIF4G 1 has been the focus of extensive studies.