Epidermal growth factor receptor
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![EGFR signaling cascades](/Images/godic/202501/10/EGFR_signaling_pathway.svg2808.png")
![Diagram of the EGF receptor highlighting important domains](/Images/godic/202501/10/EGF_Receptor2808.jpg")
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.