Ebastine (trade names Evastin, Kestine, Ebastel, Aleva, Ebatrol) is a H₁ antihistamine with low potential for causing drowsiness.

It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H₁ receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.