Driftsethe is a village and a former municipality in the district of Cuxhaven, in Lower Saxony, Germany. Since 1 January 2014, it is part of the municipality Hagen im Bremischen.

Driftsethe belonged to the Prince-Archbishopric of Bremen, established in 1180. In 1648 the Prince-Archbishopric was transformed into the Duchy of Bremen, which was first ruled in personal union by the Swedish Crown - interrupted by a Danish occupation (1712–1715) - and from 1715 on by the Hanoverian Crown. In 1807 the ephemeric Kingdom of Westphalia annexed the Duchy, before France annexed it in 1810. In 1813 the Duchy was restored to the Electorate of Hanover, which - after its upgrade to the Kingdom of Hanover in 1814 - incorporated the Duchy in a real union and the Ducal territory, including Driftsethe, became part of the new Stade Region, established in 1823.