DNA-binding domain
（重定向自DNA binding domain）
![Example of a DNA-binding domain in the context of a protein. The N-terminal DNA-bindng domain (labeled) of Lac repressor is regulated by a C-terminal regulatory domain (labeled). The regulatory domain binds an allosteric effector molecule (green). The allosteric response of the protein is communicated from the regulatory domain to the DNA binding domain through the linker region.[2]](/Images/godic/202501/09/LacI_Dimer_Structure_Annotated1011.png")
![Crystallographic structure (PDB: 1R4O) of a dimer of the zinc finger containing DBD of the glucocorticoid receptor (top) bound to DNA (bottom). Zinc atoms are represented by grey spheres and the coordinating cysteine sidechains are depicted as sticks.](/Images/godic/202501/09/1r4o1011.png")
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. Some DNA-binding domains may also include nucleic acids in their folded structure.