丙二酸二甲酯（Dimethyl malonate）是由丙二酸与甲醇的酯化反应得到的二酯，在有机合成上作为巴比妥酸的前体。

丙二酸二甲酯可由甲缩醛与CO反应制得：

Dimethyl malonate' is a diester derivative of malonic acid. It is a common reagent for organic synthesis, e.g. as a precursor for barbituric acid. It is used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.