硫酸二乙酯是硫酸与两分子乙醇形成的硫酸酯。

为无色油状液体，有薄荷香。不溶于水，溶于乙醚和乙醇。遇水缓慢分解，热水中剧烈分解为硫酸单乙酯。有毒。可能致癌。

Diethyl sulfate is a highly toxic and likely carcinogenic chemical compound with formula (C₂H₅)₂SO₄. It occurs as a colorless, oily liquid with a faint peppermint odor and is corrosive.

Diethyl sulfate is used as an alkylating agent to prepare ethyl derivatives of phenols, amines, and thiols. It is used to manufacture dyes and textiles.