己烯雌酚，非甾体雌激素类药物，于1938年首次合成。1971年，人们发现孕妇服用己烯雌酚后会导致畸胎。

己烯雌酚为无色结晶性粉末，几乎不溶于水，溶于有机溶剂。

Diethylstilbestrol (DES) (INN, USAN, BAN), also known formerly and inappropriately as stilboestrol (BAN), is a synthetic, non-steroidal estrogen of the stilbestrol group that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.