Diethylaminoethyl cellulose
![Schematic structure of DEAE-C: positively charged diethylaminoethanol groups can bind negative ions](/Images/godic/202501/09/Diethylaminoethylcellulose1804.png")
Diethylaminoethyl cellulose (DEAE-C) is a positively charged resin used in ion exchange chromatography, a type of column chromatography, used in protein and nucleic acid purification/separation. Gel matrix beads are derivatized with diethylaminoethanol (DEAE) and lock negatively charged proteins or nucleic acids into the matrix, until released by increasing the salt concentration of the solvent. DE52 has a pKa of 11.5.