Bioaccumulation refers to the accumulation of substances, such as pesticides, or other chemicals in an organism. Bioaccumulation occurs when an organism absorbs a - possibly toxic - substance at a rate faster than that at which the substance is lost by catabolism and excretion. Thus, the longer the biological half-life of a toxic substance the greater the risk of chronic poisoning, even if environmental levels of the toxin are not very high. Bioaccumulation, for example in fish, can be predicted by models. Hypotheses for molecular size cutoff criteria for use as bioaccumulation potential indicators are not supported by data. Biotransformation can strongly modify bioaccumulation of chemicals in an organism.