南美响尾蛇（Crotalus durissus）是一种分布在南美洲的响尾蛇。牠们是属内分布最广的物种，并在其出没的一些地区引发毒蛇咬伤的救治难题。其下已发现了8个亚种。

南美响尾蛇可以长达1.8米，颈部到头部有两道明显的黑线（其实视脊椎骨的突起痕迹）。

Common names: South American rattlesnake, tropical rattlesnake, more.

Crotalus durissus is a venomous pit viper species found in South America. The most widely distributed member of its genus, this species poses a serious medical problem in many parts of its range. Currently, nine subspecies are recognized, including the nominate subspecies described here.